Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The
overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …

Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively
important organic components of bile, where they are the main driving force of the osmotic …

Multidrug resistance is a major obstacle to successful cancer treatment. One mechanism by
which cells can become resistant to chemotherapy is the expression of ABC transporters that …

Chemotherapy is currently one of the most effective ways to treat metastatic cancers.
However, of the various mechanisms that are involved in conferring resistance, upregulation …

▪ Abstract The protein variously named ABCG2/BCRP/MXR/ABCP is a recently described
ATP-binding cassette (ABC) transporter originally identified by its ability to confer drug …

The brain is lipid‐rich compared to other organs and although previous studies have
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …

ABCG2 was discovered in multi-drug-resistant cancer cells, with the identification of
chemotherapeutic agents, such as mitoxantrone, flavopiridol, methotrexate and irinotecan as …

Roughly one-third of all proteins reside in biological membranes [1, 2]. Integral membrane
proteins (IMPs), which can only be released from the membrane by disruption of the …