Regulation of small gtpases by gefs, gaps, and gdis
J Cherfils, M Zeghouf - Physiological reviews, 2013 - journals.physiology.org
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
ARF GTPases and their GEFs and GAPs: concepts and challenges
E Sztul, PW Chen, JE Casanova… - Molecular biology of …, 2019 - Am Soc Cell Biol
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …
required to develop models of its actions in cells. Studying a protein family in the aggregate …
The Ras superfamily at a glance
K Wennerberg, KL Rossman… - Journal of cell …, 2005 - journals.biologists.com
GXXXXGKS/T; G2, T; G3, DXXGQ/H/T; G4, T/NKXD; and G5, C/SAK/L/T (Bourne et al.,
1991)(Fig. S1 in supplementary material). Together, these elements make up an~ 20 kDa G …
1991)(Fig. S1 in supplementary material). Together, these elements make up an~ 20 kDa G …
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
The protein kinase PINK 1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65,
and phosphoUb activates the E3 ligase Parkin allosterically. Here, we show that PINK 1 can …
and phosphoUb activates the E3 ligase Parkin allosterically. Here, we show that PINK 1 can …
[HTML][HTML] ARF proteins: roles in membrane traffic and beyond
C D'Souza-Schorey, P Chavrier - Nature reviews Molecular cell biology, 2006 - nature.com
The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …
The Ras protein superfamily: evolutionary tree and role of conserved amino acids
The Ras superfamily is a fascinating example of functional diversification in the context of a
preserved structural framework and a prototypic GTP binding site. Thanks to the availability …
preserved structural framework and a prototypic GTP binding site. Thanks to the availability …
Structure-function relationships of the G domain, a canonical switch motif
A Wittinghofer, IR Vetter - Annual review of biochemistry, 2011 - annualreviews.org
GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …
Structural basis for the docking of mTORC1 on the lysosomal surface
The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth
in response to nutrients and growth factors. Nutrients promote its translocation to the …
in response to nutrients and growth factors. Nutrients promote its translocation to the …
The small G proteins of the Arf family and their regulators
AK Gillingham, S Munro - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …
pathways. The majority of such small G proteins are members of the Rab family, which are …
Assembly dynamics of the bacterial MinCDE system and spatial regulation of the Z ring
J Lutkenhaus - Annu. Rev. Biochem., 2007 - annualreviews.org
The positioning of a cytoskeletal element that dictates the division plane is a fundamental
problem in biology. The assembly and positioning of this cytoskeletal element has to be …
problem in biology. The assembly and positioning of this cytoskeletal element has to be …