Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein
interactions. Understanding the role of the multiple structural and post-translational …

Proteins are constantly challenged by environmental stress conditions that threaten their
structure and function. Especially problematic are oxidative, acid, and severe heat stress …

Oxygen is the sustenance of aerobic life and yet is highly toxic. In early life, antioxidants
functioned solely to defend against toxic effects of reactive oxygen species (ROS). Later, as …

Standing among the front defense strategies against pathogens, host phagocytic cells
release various oxidants. Therefore, pathogens have to cope with stressful conditions at the …

Understanding the mechanisms of protein function is indispensable for many biological
applications, such as protein engineering and drug design. However, experimental …

So-called 1-Cys peroxiredoxins (Prx) employ only one cysteine residue for the reduction of
hydroperoxides and require an external thiol for the reduction of a reactive sulfenic acid …

Peroxiredoxins (PRDXs) are abundant peroxidases present in all kingdoms of life. Recently,
they have been shown to also carry out additional roles as molecular chaperones. To …

Peroxiredoxins have a long-established cellular function as regulators of redox metabolism
by catalyzing the reduction of peroxides (eg, H2O2, lipid peroxides) with high catalytic …

Abstract Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as
peroxidases under non-stress conditions or as chaperones during stress. The mechanism …

Aspergillus fumigatus is an important fungal pathogen that causes allergic reactions but also
life-threatening infections. One of the most abundant A. fumigatus proteins is Asp f3. This …