Contactin‐associated protein‐like 2, a protein of the neurexin family involved in several human diseases
M Saint‐Martin, B Joubert… - European Journal of …, 2018 - Wiley Online Library
Abstract Contactin‐associated protein‐like 2 (CASPR2) is a cell adhesion protein of the
neurexin family. Proteins of this family have been shown to play a role in the development of …
neurexin family. Proteins of this family have been shown to play a role in the development of …
New considerations for hiPSC-based models of neuropsychiatric disorders
GE Hoffman, N Schrode, E Flaherty… - Molecular psychiatry, 2019 - nature.com
The development of human-induced pluripotent stem cells (hiPSCs) has made possible
patient-specific modeling across the spectrum of human disease. Here, we discuss recent …
patient-specific modeling across the spectrum of human disease. Here, we discuss recent …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
GE Hoffman, BJ Hartley, E Flaherty, I Ladran… - Nature …, 2017 - nature.com
The power of human induced pluripotent stem cell (hiPSC)-based studies to resolve the
smaller effects of common variants within the size of cohorts that can be realistically …
smaller effects of common variants within the size of cohorts that can be realistically …
Dysregulation of miRNA-9 in a subset of schizophrenia patient-derived neural progenitor cells
Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for
schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control …
schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control …
In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain
Background Intrauterine exposure to maternal smoking is linked to impaired executive
function and behavioral problems in the offspring. Maternal smoking is associated with …
function and behavioral problems in the offspring. Maternal smoking is associated with …
Genetics of schizophrenia: ready to translate?
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
CNTNAP2 stabilizes interneuron dendritic arbors through CASK
Contactin associated protein-like 2 (CNTNAP2) has emerged as a prominent susceptibility
gene implicated in multiple complex neurodevelopmental disorders, including autism …
gene implicated in multiple complex neurodevelopmental disorders, including autism …
Mental health dished up—the use of iPSC models in neuropsychiatric research
RV McNeill, GC Ziegler, F Radtke, M Nieberler… - Journal of Neural …, 2020 - Springer
Genetic and molecular mechanisms that play a causal role in mental illnesses are
challenging to elucidate, particularly as there is a lack of relevant in vitro and in vivo models …
challenging to elucidate, particularly as there is a lack of relevant in vitro and in vivo models …
Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder: lessons from: CNTNAP2:: ADGRL3:, and: PARK2
E Dalla Vecchia, N Mortimer, VS Palladino… - Psychiatric …, 2019 - journals.lww.com
Animal and cellular models are essential tools for all areas of biological research including
neuroscience. Model systems can also be used to investigate the pathophysiology of …
neuroscience. Model systems can also be used to investigate the pathophysiology of …