Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Cancer immunotherapy has gained momentum for treating malignant tumors over the past
decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have …

Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …

Epithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The
standard-of-care treatment for EOC is platinum-based chemotherapy such as cisplatin …

Abstract Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play
important roles in cancer stemness, respectively. However, little is known about interaction …

Cancer immunotherapy has emerged as a promising strategy for the treatment of many
forms of cancer by stimulating body's own immune system. This therapy not only eradicates …

High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors
where they portend adverse outcomes, although how they function in cancer remains …

The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae.
Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs …

The high mobility group A1 (HMGA1) gene plays an important role in numerous malignant
cancers. HMGA1 is an oncofoetal gene, and we have a certain understanding of the …

HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …