Research on the neurobiology of the kynurenine pathway has suffered years of relative
obscurity because tryptophan degradation, and its involvement in both physiology and major …

Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in
neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is …

Human immunodeficiency virus (HIV)‐associated neurocognitive disorders (HANDs) remain
among the most common disorders in people infected with HIV, even in an era when potent …

There is good evidence that the kynurenine pathway (KP) and one of its end products,
quinolinic acid (QUIN) play a role in the pathogenesis of several major neurological …

Cognitive disorders, vacuolar myelopathy, and sensory neuropathies associated with HIV
are the most common disorders in patients with HIV AIDS, and are the focus of this review …

Abstract Th17-polarized CD4+ effector T-cells together with their immunosuppressive
regulatory T-cell (Treg) counterparts, with transcriptional profiles governed by the lineage …

HIV-1 invades the central nervous system (CNS) in the context of acute infection, persists
thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that …

Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for
NAD+, an important enzymatic cofactor for enzymes such as the DNA repair protein PARP …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of
dopaminergic neurons and localized neuroinflammation occurring in the midbrain several …

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can result in neurological dysfunction with devastating consequences in a significant …