Active matter at the interface between materials science and cell biology

D Needleman, Z Dogic - Nature reviews materials, 2017 - nature.com
The remarkable processes that characterize living organisms, such as motility, self-healing
and reproduction, are fuelled by a continuous injection of energy at the microscale. The field …

E-cadherin junctions as active mechanical integrators in tissue dynamics

T Lecuit, AS Yap - Nature cell biology, 2015 - nature.com
During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in
mechanically coupling the contractile cortices of cells together, thereby distributing the …

Actin cortex architecture regulates cell surface tension

P Chugh, AG Clark, MB Smith, DAD Cassani… - Nature cell …, 2017 - nature.com
Animal cell shape is largely determined by the cortex, a thin actin network underlying the
plasma membrane in which myosin-driven stresses generate contractile tension. Tension …

Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
This is an overview of theoretical approaches to semiflexible polymers and their networks.
Such semiflexible polymers have large bending rigidities that can compete with the entropic …

Mechanical properties of the cytoskeleton and cells

AF Pegoraro, P Janmey… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
The cytoskeleton is the major mechanical structure of the cell; it is a complex, dynamic
biopolymer network comprising microtubules, actin, and intermediate filaments. Both the …

Actin cortex mechanics and cellular morphogenesis

G Salbreux, G Charras, E Paluch - Trends in cell biology, 2012 - cell.com
The cortex is a thin, crosslinked actin network lying immediately beneath the plasma
membrane of animal cells. Myosin motors exert contractile forces in the meshwork. Because …

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

AC Martin, B Goldstein - Development, 2014 - journals.biologists.com
Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex

MP Murrell, ML Gardel - Proceedings of the National …, 2012 - National Acad Sciences
Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross-
linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted …

Physics of adherent cells

US Schwarz, SA Safran - Reviews of Modern Physics, 2013 - APS
One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …

The actin cytoskeleton as an active adaptive material

S Banerjee, ML Gardel… - Annual review of …, 2020 - annualreviews.org
Actin is the main protein used by biological cells to adapt their structure and mechanics to
their needs. Cellular adaptation is made possible by molecular processes that strongly …