Low back pain is the main cause of disability and is associated with intervertebral disc
degeneration. Contemporary treatments are limited to palliative therapeutics or aggressive …

Low back pain is the primary cause of disability and is highly associated with progression of
intervertebral disc degeneration. Current treatment options are limited and fail to address the …

Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …

Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and
changes can help flag pathological processes such as neurodegeneration and …

Functional changes of nucleus pulposus cells (NPCs) are considered to be the initiating
factors of intervertebral disc degeneration (IDD). In this study, we investigated whether …

Introduction In this study, magnetic resonance imaging data was used to (1) model IVD‐
specific gradients of glucose, oxygen, lactate, and pH; and (2) investigate possible effects of …

The present study aimed to explore the underlying mechanisms of bone morphogenetic
protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD …

Intervertebral disk (IVD) degeneration (IVDD) can cause various spinal degenerative
diseases. Cumulative evidence has indicated that IVDD can result from inflammation …

Intervertebral disc degeneration (IVDD) is an important risk factor of low back pain. We
previously found upregulated markers of fibrosis, the late stage of chronic inflammation, in …

Emerging evidence suggests that microRNAs (miRNAs, miRs) play important roles in the
development of intervertebral disc degeneration (IVDD). Nonetheless, the expression level …