Induced pluripotent stem cells and their use in human models of disease and development
P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
[HTML][HTML] Chemically induced reprogramming to reverse cellular aging
JH Yang, CA Petty, T Dixon-McDougall… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
TGFβ signalling in context
J Massagué - Nature reviews Molecular cell biology, 2012 - nature.com
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell
fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem …
fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem …
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
The induction of pluripotent stem cells (iPSCs) by defined factors is poorly understood
stepwise. Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary …
stepwise. Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary …
Mechanisms and models of somatic cell reprogramming
Conversion of somatic cells to pluripotency by defined factors is a long and complex process
that yields embryonic-stem-cell-like cells that vary in their developmental potential. To …
that yields embryonic-stem-cell-like cells that vary in their developmental potential. To …
[HTML][HTML] Conversion of mouse and human fibroblasts into functional spinal motor neurons
The mammalian nervous system comprises many distinct neuronal subtypes, each with its
own phenotype and differential sensitivity to degenerative disease. Although specific …
own phenotype and differential sensitivity to degenerative disease. Although specific …
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expression
of defined embryonic factors. However, little is known of the molecular mechanisms …
of defined embryonic factors. However, little is known of the molecular mechanisms …