TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

We undertook a comprehensive proteogenomic characterization of 95 prospectively
collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This …

Acne vulgaris is a cutaneous chronic inflammatory disorder with complex pathogenesis.
Four factors play vital roles in acne pathophysiology: hyperseborrhea and dysseborrhea …

TP53 is a tumor suppressor gene which is commonly mutated in various cancers including
breast cancer. Alterations in the gene lead to an altered expression of various genes that are …

In this unprecedented study, the anticancer properties of gold nanoparticles synthesized
using Achillea biebersteinii flower extractwere investigated. Nanoparticle synthesis using …

Here, we show that the tumor suppressor phosphatase and tensin homolog deleted from
chromosome 10 (PTEN) sensitizes cells to ferroptosis, an iron-dependent form of cell death …

Awareness of the importance of immunity in controlling cancer development triggered
research into the impact of its key oncogenic drivers on the immune response, as well as …

This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne
and isotretinoin's mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin …

Abstract Mitochondria-associated membranes (MAM), physical platforms that enable
communication between mitochondria and the endoplasmic reticulum (ER), are enriched …