Highlights•Cell autonomous polarity, its transmission through division, are unifying themes
for centrosome/primary cilium functions.•Adhesion-dependent acto-myosin fibers play a …

The centrosome, consisting of centrioles and the associated pericentriolar material, is the
main microtubule-organizing centre (MTOC) in animal cells. During most of interphase, the …

Breast cancer risk for carriers of BRCA1 pathological variants is modified by genetic factors.
Genetic variation in HMMR may contribute to this effect. However, the impact of risk …

Microtubules are essential for intracellular organization and chromosome segregation. They
are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC …

The gamma-tubulin ring complex (γ-TuRC) is the principal microtubule nucleation template
in vertebrates. Recent cryo-EM reconstructions visualized the intricate quaternary structure …

Nuclear envelope (NE) assembly defects cause chromosome fragmentation, cancer, and
aging. However, major questions about the mechanism of NE assembly and its relationship …

Uncontrolled cell proliferation leads to several pathologies, including cancer. Thus, this
process must be tightly regulated. The cell cycle accounts for cell proliferation, and its …

The Arp2/3 complex is an actin nucleator with well-characterized activities in cell
morphogenesis and movement, but its roles in nuclear processes are relatively …

The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …

The centrosome is a main orchestrator of the animal cellular microtubule cytoskeleton.
Dissecting its structure and assembly mechanisms has been a goal of cell biologists for over …