Opportunities and tradeoffs in single-cell transcriptomic technologies
MI Conte, A Fuentes-Trillo, CD Conde - Trends in Genetics, 2024 - cell.com
Recent technological and algorithmic advances enable single-cell transcriptomic analysis
with remarkable depth and breadth. Nonetheless, a persistent challenge is the compromise …
with remarkable depth and breadth. Nonetheless, a persistent challenge is the compromise …
Extrinsic and intrinsic drivers of natural killer cell clonality
T Rückert, C Romagnani - Immunological Reviews, 2024 - Wiley Online Library
Clonal expansion of antigen‐specific lymphocytes is the fundamental mechanism enabling
potent adaptive immune responses and the generation of immune memory. Accompanied …
potent adaptive immune responses and the generation of immune memory. Accompanied …
Random allelic expression in the adult human body
SN Kravitz, E Ferris, MI Love, A Thomas, AR Quinlan… - Cell reports, 2023 - cell.com
Genes are typically assumed to express both parental alleles similarly, yet cell lines show
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …
MSL2 ensures biallelic gene expression in mammals
In diploid organisms, biallelic gene expression enables the production of adequate levels of
mRNA,. This is essential for haploinsufficient genes, which require biallelic expression for …
mRNA,. This is essential for haploinsufficient genes, which require biallelic expression for …
Highly structured homolog pairing reflects functional organization of the Drosophila genome
Trans-homolog interactions have been studied extensively in Drosophila, where homologs
are paired in somatic cells and transvection is prevalent. Nevertheless, the detailed structure …
are paired in somatic cells and transvection is prevalent. Nevertheless, the detailed structure …
Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells
Stable changes in chromatin states and gene expression in cells of the immune system form
the basis for memory of infections and other challenges. Here, we used naturally occurring …
the basis for memory of infections and other challenges. Here, we used naturally occurring …
Perspectives on allele-specific expression
Diploidy has profound implications for population genetics and susceptibility to genetic
diseases. Although two copies are present for most genes in the human genome, they are …
diseases. Although two copies are present for most genes in the human genome, they are …
Parental bias in expression and interaction of genes in the equine placenta
P Dini, T Kalbfleisch… - Proceedings of the …, 2021 - National Acad Sciences
Most autosomal genes in the placenta show a biallelic expression pattern. However, some
genes exhibit allele-specific transcription depending on the parental origin of the …
genes exhibit allele-specific transcription depending on the parental origin of the …
Introns control stochastic allele expression bias
B Sands, S Yun, AR Mendenhall - Nature Communications, 2021 - nature.com
Monoallelic expression (MAE) or extreme allele bias can account for incomplete penetrance,
missing heritability and non-Mendelian diseases. In cancer, MAE is associated with shorter …
missing heritability and non-Mendelian diseases. In cancer, MAE is associated with shorter …
The good, the bad, and the ugly: Evolutionary and pathological aspects of gene dosage alterations
MF Basilicata, CI Keller Valsecchi - PLoS Genetics, 2021 - journals.plos.org
Diploid organisms contain a maternal and a paternal genome complement that is thought to
provide robustness and allow developmental progression despite genetic perturbations that …
provide robustness and allow developmental progression despite genetic perturbations that …