Recent technological and algorithmic advances enable single-cell transcriptomic analysis
with remarkable depth and breadth. Nonetheless, a persistent challenge is the compromise …

Clonal expansion of antigen‐specific lymphocytes is the fundamental mechanism enabling
potent adaptive immune responses and the generation of immune memory. Accompanied …

Genes are typically assumed to express both parental alleles similarly, yet cell lines show
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …

In diploid organisms, biallelic gene expression enables the production of adequate levels of
mRNA,. This is essential for haploinsufficient genes, which require biallelic expression for …

Trans-homolog interactions have been studied extensively in Drosophila, where homologs
are paired in somatic cells and transvection is prevalent. Nevertheless, the detailed structure …

Stable changes in chromatin states and gene expression in cells of the immune system form
the basis for memory of infections and other challenges. Here, we used naturally occurring …

Diploidy has profound implications for population genetics and susceptibility to genetic
diseases. Although two copies are present for most genes in the human genome, they are …

Most autosomal genes in the placenta show a biallelic expression pattern. However, some
genes exhibit allele-specific transcription depending on the parental origin of the …

Monoallelic expression (MAE) or extreme allele bias can account for incomplete penetrance,
missing heritability and non-Mendelian diseases. In cancer, MAE is associated with shorter …

Diploid organisms contain a maternal and a paternal genome complement that is thought to
provide robustness and allow developmental progression despite genetic perturbations that …