Cardiovascular disease is still one of the leading causes of death in the world, and heart
transplantation is the current major treatment for end-stage cardiovascular diseases …

Cardiac muscle contraction is distinct from the contraction of other muscle types. The heart
continuously undergoes contraction–relaxation cycles throughout an animal's lifespan. It …

The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to
contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to …

Aberrant regulation of myocardial force production represents an early biomechanical defect
associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly …

Calcineurin (CaN) is a calcium-dependent phosphatase involved in numerous signaling
pathways. Its activation is in part driven by the binding of calmodulin (CaM) to a CaM …

The function of muscle to properly contract and relax is essential to multiple physiological
processes and their adaptation to stress and pathological conditions. The limited ability of …

Aberrant regulation of myocardial force production represents an early biomechanical defect
associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly …

Cardiomyopathies are a heterogenous group of myocardial disorders that are frequently
associated with a genetic etiology. The cardiac/slow skeletal troponin C gene (TNNC1) …

Calmodulin (CaM) binds to calcineurin (CaN)'s CaM-recognition motif with an affinity in the
picomolar range, however this alone is insufficient to fully activate CaN. It has been shown …