Fundamentals of redox regulation in biology
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …
Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury
Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine
(8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic …
(8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic …
An allosteric redox switch involved in oxygen protection in a CO2 reductase
Metal-dependent formate dehydrogenases reduce CO2 with high efficiency and selectivity,
but are usually very oxygen sensitive. An exception is Desulfovibrio vulgaris W/Sec-FdhAB …
but are usually very oxygen sensitive. An exception is Desulfovibrio vulgaris W/Sec-FdhAB …
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design
LM Funk, G Poschmann… - Nature …, 2024 - nature.com
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for
preventing future COVID outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine …
preventing future COVID outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine …
The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease
The main protease of SARS-CoV-2 (Mpro) is an important target for developing COVID-19
therapeutics. Recent work has highlighted Mpro's susceptibility to undergo redox-associated …
therapeutics. Recent work has highlighted Mpro's susceptibility to undergo redox-associated …
A systematic survey of reversibly covalent dipeptidyl inhibitors of the SARS-CoV-2 main protease
SARS-CoV-2, the COVID-19 pathogen, relies on its main protease (MPro) for replication and
pathogenesis. MPro is a demonstrated target for the development of antivirals for SARS-CoV …
pathogenesis. MPro is a demonstrated target for the development of antivirals for SARS-CoV …
A Novel Y-shaped, S–O–N–O–S-bridged cross-link between three residues C22, C44, and K61 is frequently observed in the SARS-CoV-2 main Protease
KS Yang, LR Blankenship, STA Kuo… - ACS chemical …, 2023 - ACS Publications
As the COVID-19 pathogen, SARS-CoV-2 relies on its main protease (MPro) for
pathogenesis and replication. During crystallographic analyses of MPro crystals that were …
pathogenesis and replication. During crystallographic analyses of MPro crystals that were …
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
PYA Reinke, EE de Souza, S Günther, S Falke… - Communications …, 2023 - nature.com
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-
CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro …
CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro …
Mechanisms of Cysteine‐Lysine Covalent Linkage—The Role of Reactive Oxygen Species and Competition with Disulfide Bonds
Recently, a new naturally occurring covalent linkage was characterised, involving a cysteine
and a lysine, bridged through an oxygen atom. The latter was dubbed as the NOS bond …
and a lysine, bridged through an oxygen atom. The latter was dubbed as the NOS bond …
Degradation of low-density polyethylene by the bacterium Rhodococcus sp. C-2 isolated from seawater
Abstract Low-density polyethylene (LDPE), which accounts for 20% of the global plastic
production, is discharged in great quantities into the ocean, threatening marine life and …
production, is discharged in great quantities into the ocean, threatening marine life and …