Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Bone consists of separate inner endosteal and outer periosteal compartments, each with
distinct contributions to bone physiology and each maintaining separate pools of cells owing …

Critical-sized bone defects often lead to non-union and full-thickness defects of the
calvarium specifically still present reconstructive challenges. In this study, we show that …

Limited stem cells, poor stretchability and mismatched interface fusion have plagued the
reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable …

Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of
the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis …

Craniosynostosis results from premature fusion of the cranial suture (s), which contain
mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with …

Bone-related maladies are a major health burden on modern society. Loss of skeletal
integrity and regeneration capacity through aging, obesity, and disease follows from a …

Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem
cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as …

Mesenchymal stem cells (MSCs) secrete paracrine trophic factors that are beneficial for
tissue regeneration. In this study, a sponge-like scaffold with hierarchical and interconnected …