Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in
5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric …

Background Hirschsprung's disease (HSCR) is a serious congenital bowel disorder with a
prevalence of 1/5000. Currently, there is a lack of systematically developed guidelines to …

The gastrointestinal tract contains its own set of intrinsic neuroglial circuits—the enteric
nervous system (ENS)—which detects and responds to diverse signals from the …

Diagnosis or exclusion of Hirschsprung disease (HSCR) is a frequent exercise in any
pediatric hospital. Although HSCR may present at different ages and with varied clinical …

Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …

Hirschsprung-associated enterocolitis (HAEC) was described in 1886 by Harald
Hirschsprung and is a potentially deadly complication of Hirschsprung Disease. HAEC is …

Children with Hirschsprung disease have postoperative long-term sequelae in defecation
that contribute to morbidity and mortality and significantly impact their quality of life. Pediatric …

Endorectal pullthrough surgery is integral in the treatment of patients with Hirschsprung
disease. Several different surgical procedures exist, which share as common goals to excise …

After operative intervention for Hirschsprung disease (HD) a child should thrive, be fecally
continent, and avoid recurrent episodes of abdominal distention and enterocolitis. This is …

Although most children with Hirschsprung disease ultimately achieve functional and
comfortable stooling, some will experience a variety of problems after pull-through surgery …