Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of
schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an …

In 1976, I (JTC) finished my psychiatric residency, received my first National Institutes of
Health grant, opened my laboratory, and took responsibility for the Schizophrenia Outpatient …

Abstract Glycine transporters (GlyTs) are Na+/Cl−-dependent neurotransmitter transporters,
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …

Addiction to alcohol and drugs is a major social and economic problem, and there is
considerable interest in understanding the molecular mechanisms that promote addictive …

Abstract d-Serine is a physiological coagonist of NMDA receptors involved in synaptic
plasticity, neurodevelopment, and neurodegeneration. d-Serine is synthesized by the …

Despite the identification of a growing number of genetic risk loci for substance use traits
(SUTs), the impact of these loci on protein abundance and the potential utility of relevant …

Glycine plays two roles in neurotransmission. In caudal areas like the spinal cord and the
brainstem, it acts as an inhibitory neurotransmitter, but in all regions of the CNS, it also works …

Based on the clinical observations of severe cognitive deficits in schizophrenia patients and
the relationship between environmental parameters and the severity of schizophrenia …

One of the principal barriers to overcoming addiction is the propensity to relapse, even after
months or years of abstinence. Relapse can be precipitated by cues and contexts …

Schizophrenia is a severe psychiatric disorder which is worsened substantially by substance
abuse/addiction. Substance abuse affects nearly 50% of individuals with schizophrenia …