Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

The Hippo pathway is a conserved signaling pathway originally defined in Drosophila
melanogaster two decades ago. Deregulation of the Hippo pathway leads to significant …

YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How
cells ensure the selective activation of YAP effector genes is unknown. This knowledge is …

Abstract Background Mesenchymal stem cells (MSCs) are multipotent stem cells that are
able to differentiate into several cell types, including cartilage, fat, and bone. As a common …

The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …

The epiblast is a pluripotent cell population first formed in preimplantation embryos, and its
quality is important for proper development. Here, we examined the mechanisms of epiblast …

While several organs in mammals retain partial regenerative capability following tissue
damage, the underlying mechanisms remain unclear. Recently, the Hippo signaling …