The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

The pH in tumour cells and the tumour microenvironment has played important roles in
cancer development and treatment. It was thought that both the extracellular and …

The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …

Background Macropinocytosis, an important nutrient-scavenging pathway in certain cancer
cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor …

Dynamics of epithelial monolayers has recently been interpreted in terms of a jamming or
rigidity transition. How cells control such phase transitions is, however, unknown. Here we …

Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility
to inhibitors of Na+/H+ exchange. Yet, the functional relationship between Na+/H+ exchange …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Wound healing is essential for maintaining the integrity of multicellular organisms. In every
species studied, disruption of an epithelial layer instantaneously generates endogenous …

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis
transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss …

Macropinocytosis has received increasing attention in recent years for its various roles in
nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases …