BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

Several interventions have recently emerged that were proposed to reverse rather than just
attenuate aging, but the criteria for what it takes to achieve rejuvenation remain …

Compared to women, increasing male age is not accompanied by such marked changes in
reproductive function but changes certainly do happen. These include alterations to the …

STUDY QUESTION Is sperm epigenetic aging (SEA) associated with probability of
pregnancy among couples in the general population? SUMMARY ANSWER We observed a …

Advanced paternal age is associated with increased risks for reproductive and offspring
medical problems. Accumulating evidence suggests age-related changes in the sperm …

Background: The organochlorine dichlorodiphenyltrichloroethane (DDT) is banned
worldwide owing to its negative health effects. It is exceptionally used as an insecticide for …

Paternal age at conception has been increasing. In this review, we first present the results
from the major mammalian animal models used to establish that increasing paternal age …