Glutamatergic excitatory transmission is implicated in physiological and pathological
conditions like learning, memory, neuronal plasticity and emotions, while glutamatergic …

The metabotropic glutamate (mGlu) receptors are a group of Class C seven-transmembrane
spanning/G protein-coupled receptors (7TMRs/GPCRs). These receptors are activated by …

In view of the fact that the G-protein-coupled receptors (GPCRs) sit at the top of the signaling
pathways triggering a diverse range of signaling cascades towards a cellular event, GPCRs …

Glutamate, the major excitatory neurotransmitter, functions in the brain via activation of
ligand-gated cation channels and also the eight subtypes of class CG protein-coupled …

Abstract Development of SAR in an aryl ether series of mGlu 5 NAMs leading to the
identification of tool compound VU0409106 is described in this Letter. VU0409106 is a …

Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinyl
imidazoles series of mGlu5 receptor negative allosteric modulators (mGluR5 NAMs) using a …

Metabotropic glutamate (mGlu) receptors (nomenclature as agreed by the NC-IUPHAR
Subcommittee on Metabotropic Glutamate Receptors [351]) are a family of G protein …

Purpose Drug repositioning strategies were employed to explore new therapeutic
indications for existing drugs that may exhibit dual negative mGluR1/5 modulating activities …

Cocaine is a powerful and highly addictive stimulant that disrupts the normal reward circuitry
in the central nervous system (CNS), producing euphoric effects. Cocaine use can lead to …

A series of novel 2, 6-diphenyl substituted imidazo [4, 5-b] pyridines was designed and
synthesized using optimized Suzuki cross coupling to evaluate their biological activity in …