Metagenomic approaches to analyze antimicrobial resistance: an overview

VAC De Abreu, J Perdigão, S Almeida - Frontiers in genetics, 2021 - frontiersin.org
Antimicrobial resistance is a major global public health problem, which develops when
pathogens acquire antimicrobial resistance genes (ARGs), primarily through genetic …

Forensic applications of microbiomics: a review

JM Robinson, Z Pasternak, CE Mason… - Frontiers in …, 2021 - frontiersin.org
The rise of microbiomics and metagenomics has been driven by advances in genomic
sequencing technology, improved microbial sampling methods, and fast-evolving …

MEGARes 2.0: a database for classification of antimicrobial drug, biocide and metal resistance determinants in metagenomic sequence data

E Doster, SM Lakin, CJ Dean, C Wolfe… - Nucleic acids …, 2020 - academic.oup.com
Antimicrobial resistance (AMR) is a threat to global public health and the identification of
genetic determinants of AMR is a critical component to epidemiological investigations. High …

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

D Butler, C Mozsary, C Meydan, J Foox… - Nature …, 2021 - nature.com
In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) killed over a million people, including> 25,000 in New York City (NYC) alone. The …

Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

KR Chng, C Li, D Bertrand, AHQ Ng, JS Kwah… - Nature medicine, 2020 - nature.com
Although disinfection is key to infection control, the colonization patterns and resistomes of
hospital-environment microbes remain underexplored. We report the first extensive genomic …

Metagraph: Indexing and analysing nucleotide archives at petabase-scale

M Karasikov, H Mustafa, D Danciu, C Barber… - BioRxiv, 2020 - biorxiv.org
The amount of biological sequencing data available in public repositories is growing
exponentially, forming an invaluable biomedical research resource. Yet, making all this …

Water and soil contaminated by arsenic: the use of microorganisms and plants in bioremediation

PN Bertin, S Crognale, F Plewniak… - … Science and Pollution …, 2021 - Springer
Owing to their roles in the arsenic (As) biogeochemical cycle, microorganisms and plants
offer significant potential for developing innovative biotechnological applications able to …

A comprehensive metagenomics framework to characterize organisms relevant for planetary protection

DC Danko, MA Sierra, JN Benardini, L Guan, JM Wood… - Microbiome, 2021 - Springer
Background Clean rooms of the Space Assembly Facility (SAF) at the Jet Propulsion
Laboratory (JPL) at NASA are the final step of spacecraft cleaning and assembly before …

M etagenomic insights into the microbial communities of inert and oligotrophic outdoor pier surfaces of a coastal city

X Tong, MHY Leung, Z Shen, JYY Lee, CE Mason… - Microbiome, 2021 - Springer
Background Studies of the microbiomes on surfaces in built environment have largely
focused on indoor spaces, while outdoor spaces have received far less attention. Piers are …

The impact of cross-kingdom molecular forensics on genetic privacy

E Elhaik, S Ahsanuddin, JM Robinson, EM Foster… - Microbiome, 2021 - Springer
Recent advances in metagenomic technology and computational prediction may
inadvertently weaken an individual's reasonable expectation of privacy. Through cross …