Troponin: the biomarker of choice for the detection of cardiac injury

L Babuin, AS Jaffe - Cmaj, 2005 - Can Med Assoc
It has been known for 50 years that transaminase activity increases in patients with acute
myocardial infarction. With the development of creatine kinase (CK), biomarkers of cardiac …

Biomarkers in acute cardiac disease: the present and the future

AS Jaffe, L Babuin, FS Apple - Journal of the American college of cardiology, 2006 - jacc.org
The use of biomarkers to aid diagnosis and treatment is increasing rapidly as genomics and
proteomics help us expand the number of markers we can use and as an improved …

Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease

FS Apple, MAM Murakami, LA Pearce, CA Herzog - Circulation, 2002 - Am Heart Assoc
Background—This study determined the prevalence of increased cardiac troponin I (cTnI)
and T (cTnT) in end-stage renal disease (ESRD) patients and whether an increased …

Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis

C DeFilippi, S Wasserman, S Rosanio, E Tiblier… - Jama, 2003 - jamanetwork.com
ContextCardiac troponin T (cTnT) and C-reactive protein (CRP) are prognostic markers in
acute coronary syndromes. However, for patients with end-stage renal disease (ESRD) the …

Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study

LK Newby, AB Storrow, WB Gibler, JL Garvey… - Circulation, 2001 - Am Heart Assoc
Background—Earlier, rapid evaluation in chest pain units may make patient care more
efficient. A multimarker strategy (MMS) testing for several markers of myocardial necrosis …

Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal …

FS Apple, MAM Murakami, LA Pearce… - Clinical …, 2004 - academic.oup.com
Background: In patients with end-stage renal disease (ESRD), the ability of single and
multiple biomarker monitoring to predict adverse outcomes has not been well established …

Prognostic value of troponin after elective percutaneous coronary intervention: a meta‐analysis

MB Nienhuis, JP Ottervanger, HJG Bilo… - Catheterization and …, 2008 - Wiley Online Library
Background: Although the prognostic importance of troponin in patients with anacute
coronary syndrome is clear, the significance of troponin elevation after elective …

Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department

F Peacock, DL Morris, S Anwaruddin… - American heart …, 2006 - Elsevier
BACKGROUND: Because of possible adverse outcomes, many of the> 6 million annual
emergency department (ED) patients with suspected acute coronary syndromes (ACS) …

Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin T–positive status: the PARAGON-B troponin T substudy

LK Newby, EM Ohman, RH Christenson, DJ Moliterno… - Circulation, 2001 - Am Heart Assoc
Background—Troponin T (TnT) is valuable for short-and long-term risk stratification of
patients with acute coronary syndromes (ACS). It also may predict which ACS patients will …

Elevations in troponin T and I are associated with abnormal tissue level perfusion: a TACTICS-TIMI 18 substudy

GC Wong, DA Morrow, S Murphy, N Kraimer, R Pai… - Circulation, 2002 - Am Heart Assoc
Background—Cardiac troponin T (cTnT) and I elevations are associated with a higher risk of
adverse events, a higher incidence of multivessel disease, complex lesions, and visible …