The constant failure of new neuroprotective therapies for ischemic stroke has partially halted
the search for new therapies in recent years, mainly because of the high investment risk …

Biomarkers are measurable substances that could be used as objective indicators for
disease diagnosis, responses to treatments, and outcomes predictions. In this review, we …

Inflammation and activation of the neuroendocrine systems comprise important aspects of
stroke pathophysiology. The present study investigated whether baseline plasma brain …

Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other
cellular components of the neurovascular unit. Several strategies have been developed …

Stroke is the second highest reason of death in the world and the leading cause of disability.
The ischemic stroke makes up the majority of stroke cases that occur due to the blockage of …

The advent of epigenetics brought in a tectonic shift in the understanding of molecular basis
of complex diseases like ischemic stroke (IS). Substantial scientific inquiry into the …

Recent studies have uncovered that accumulation of glutamate after ischaemic stroke is
closely associated with the down-regulation of glutamate transporter-1 (GLT-1) expression …

Background: Early neurological deterioration (END) following acute stroke is associated with
poorer long-term outcomes. Identification of patients at risk could assist early monitoring and …

Background Depression is a frequent mood disorder that affects around 33% of stroke
patient. Our aim was to test the possible association between plasma glutamate and the …

Background Recent Alzheimer's disease (AD) research has focused on finding biomarkers
to identify disease at the pre-clinical stage of mild cognitive impairment (MCI), allowing …