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The review deals with the release of endothelium-derived dopamine and 6-nitrodopamine (6-
ND) and its effects on isolated vascular tissues and isolated hearts. Basal release of both …

Proteinuria and increased renal reabsorption of NaCl characterize the nephrotic syndrome.
Here, we show that protein-rich urine from nephrotic rats and from patients with nephrotic …

The epithelial Na+ channel (ENaC) functions as a pathway for epithelial Na+ transport,
contributing to Na+ homeostasis and blood pressure control. Vasopressin increases ENaC …

The distal tubule of the mammalian kidney can be defined as the nephron segment between
the macula densa region and the cortical collecting tubule. It comprises several …

Our understanding of urinary concentrating and diluting mechanisms at the end of the 20th
century was based largely on data from renal micropuncture studies, isolated perfused …

In the renal collecting duct, water reabsorption is regulated by the antidiuretic hormone
vasopressin (AVP). Binding of this hormone to the vasopressin V2 receptor (V2R) leads to …

Aldosterone and vasopressin are responsible for the final adjustment of sodium and water
reabsorption in the kidney. In principal cells of the kidney cortical collecting duct (CCD), the …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

We studied here the independent roles of angiotensin II and aldosterone in regulating the
sodium chloride cotransporter (NCC) of the distal convoluted tubule. We adrenalectomized …