[HTML][HTML] Treatment with brain specific estrogen prodrug ameliorates cognitive effects of surgical menopause in mice

AE Salinero, C Abi-Ghanem, H Venkataganesh… - Hormones and …, 2024 - Elsevier
Menopause is an endocrine shift leading to increased vulnerability for cognitive impairment
and dementia risk factors, in part due to loss of neuroprotective circulating estrogens …

The Pathophysiology, Prognosis and Treatment of Hypertension in Females from Pregnancy to Post-menopause: A Review

S Li, I Tan, E Atkins, AE Schutte… - Current Heart Failure …, 2024 - Springer
Abstract Purpose of Review We summarise the physiological changes and risk factors for
hypertension in females, potential sex-specific management approaches, and long-term …

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification …

DA Hart - International Journal of Molecular Sciences, 2024 - mdpi.com
For much of human evolution, the average lifespan was< 40 years, due in part to disease,
infant mortality, predators, food insecurity, and, for females, complications of childbirth. Thus …

Effects of high fat diet on metabolic health vary by age of menopause onset

AE Salinero, H Venkataganesh… - International Journal of …, 2024 - nature.com
Menopause accelerates metabolic dysfunction, including (pre-) diabetes, obesity and
visceral adiposity. However, the effects of endocrine vs. chronological aging in this …

Associations Between Age at Menopause, Vascular Risk, and 3-Year Cognitive Change in the Canadian Longitudinal Study on Aging

M Wood Alexander, CY Wu, GT Coughlan, T Puri… - Neurology, 2024 - AAN Enterprises
Background and Objectives Mounting evidence supports sex differences in Alzheimer
disease (AD) risk. Vascular and hormonal factors may together contribute to AD risk in …

[HTML][HTML] Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake

NZ Ramli, MF Yahaya, NAM Fahami… - Experimental …, 2024 - Elsevier
The menopausal transition is a complex neuroendocrine aging process affecting brain
structure and metabolic function. Such changes are consistent with neurological sequelae …

[HTML][HTML] Reduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex

OJ Olajide, AAB Burrowes, IF da Silva, A Bergdahl… - Neuroscience, 2025 - Elsevier
Reductions in circulating estrogens can contribute to cognitive decline, in part by impairing
mitochondrial function within the hippocampal region. The entorhinal cortex provides the …

Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats

LL Fan, H Fang, JY Zheng, YH Qiu, GL Wu… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Taohong Siwu Decoction (TSD), a classic
traditional Chinese medicine formula, is used for the treatment of vascular diseases …

A fNIRS investigation of menopausal-related symptoms and brain cortical activity in menopause

Y Zhou, J Lin, C Li, Y Zheng, Z Meng, Y Teng… - Journal of Affective …, 2024 - Elsevier
Background This study aimed to delineate the association between menopausal-related
symptoms and brain cortical hemodynamics in peri-postmenopause women. Methods Cross …

[HTML][HTML] Brain Specific Estrogen Ameliorates Cognitive Effects of Surgical Menopause in Mice

AE Salinero, C Abi-Ghanem, H Venkataganesh, A Sura… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Menopause is a major endocrinological shift that leads to an increased vulnerability to the
risk factors for cognitive impairment and dementia. This is thought to be due to the loss of …