Several bacterial species have inherent ability to colonize solid tumors in vivo. However,
their natural anti-tumor activity can be enhanced by genetic engineering that enables these …

Purpose: To review the current literature concerning the use of bevacizumab in treating
neovascular disorders affecting the anterior segment ocular structures. Methods: The …

Advances in cancer therapy have been substantial in terms of molecular understanding of
disease mechanisms, however these advances have not translated into increased survival …

A living therapeutic system based on attenuated Salmonella was developed via metabolic
engineering using an aggregation-induced emission (AIE) photosensitizer MA. The …

The normal cornea is transparent, which is essential for normal vision, and although the
angiogenic factor vascular endothelial growth factor A (VEGF-A) is present in the cornea, its …

purpose. To investigate herpes stromal keratitis (HSK) immunopathology by studying HSV-1-
infected corneas that fail to develop HSK. methods. Plaque assay quantified HSV-1 in the …

Antitumour treatments are evolving, including bacteria-mediated cancer therapy which is
concurrently an ancient and cutting-edge approach. Salmonella typhimurium is a widely …

The isoform-specific role of human apolipoprotein E (apoE) has been assessed in a mouse
model of ocular herpes. Female, age-matched transgenic mice knocked-in for the human …

Antiangiogenic molecules exert a feedback control to restrain pathological angiogenesis,
which includes physical binding or inhibition of angiogenic signaling in blood vessel …

purpose. To investigate whether the induction of cytotoxic T lymphocytes (CTLs) targeting
VEGF receptor 2 inhibits corneal neovascularization caused by alkali injury. methods. H …