Organoid systems leverage the self-organizing properties of stem cells to create diverse
multi-cellular tissue proxies. Most organoid models only represent single or partial …

The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …

Stem cells (SCs) hold great promise for cell therapy, tissue engineering, and regenerative
medicine as well as pharmaceutical and biotechnological applications. They have the …

Blood vessels are fundamental to animal life and have critical roles in many diseases, such
as stroke, myocardial infarction and diabetes. The vasculature is formed by endothelial cells …

Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

The basement membrane is an important extracellular matrix that is found in all epithelial
and endothelial tissues. It maintains tissue integrity, serves as a barrier to cells and to …

Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

Since the advent of the generation of human induced pluripotent stem cells (hiPSCs),
numerous protocols have been developed to differentiate hiPSCs into cardiomyocytes and …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Stem cell fate is influenced by a number of factors and interactions that require robust control
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …