During pregnancy, the mother must adapt her body systems to support nutrient and oxygen
supply for growth of the baby in utero and during the subsequent lactation. These include …

Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …

IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a
complex molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF …

Abstract Growth hormone (GH), insulin-like growth factor (IGF)-I and insulin have potent
growth-promoting and anabolic actions. Their potential involvement in tumor promotion and …

There is increasing evidence that platelets play an important role in the process of tumor
angiogenesis. Thrombocytosis is a frequent finding in cancer patients (10–57%). Although …

Angiogenesis is the process of new blood vessel development from preexisting vasculature.
Although vascular endothelium is usually quiescent in the adult, active angiogenesis has …

The potential to block tumor growth by inhibition of the neoangiogenic process represents
an intriguing approach to the treatment of solid tumors. The high proliferation rate in the …

Lymphangiogenesis is an important process that contributes to the spread of cancer. Here
we show that insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) induce lymphangiogenesis …

In this review, we provide an overview of the role of the insulin-like growth factor (IGF)
signaling pathway in breast cancer and discuss its potential as a therapeutic target. The IGF …