Physiology of microglia

H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Cannabidiol as a therapeutic target: evidence of its neuroprotective and neuromodulatory function in Parkinson's disease

F Patricio, AA Morales-Andrade… - Frontiers in …, 2020 - frontiersin.org
The phytocannabinoids of Cannabis sativa L. have, since ancient times, been proposed as a
pharmacological alternative for treating various central nervous system (CNS) disorders …

Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors

MD Van Sickle, M Duncan, PJ Kingsley, A Mouihate… - Science, 2005 - science.org
The presence and function of CB2 receptors in central nervous system (CNS) neurons are
controversial. We report the expression of CB2 receptor messenger RNA and protein …

Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas

N Stella - Glia, 2010 - Wiley Online Library
CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they
endogenously‐produced, plant‐derived or synthetic. These receptors are expressed by …

Cannabinoid CB2 receptors: immunohistochemical localization in rat brain

JP Gong, ES Onaivi, H Ishiguro, QR Liu, PA Tagliaferro… - Brain research, 2006 - Elsevier
Brain expression of CB2 cannabinoid receptors has been much less well established and
characterized in comparison to the expression of brain CB1 receptors. Since CB2 receptors …

Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain

ES Onaivi, H Ishiguro, JP GONG, S Patel… - Annals of the New …, 2006 - Wiley Online Library
Two well‐characterized cannabinoid receptors (CBrs), CB1 and CB2, mediate the effects of
cannabinoids and marijuana use, with functional evidence for other CBrs. CB1 receptors are …

Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation

GA Cabral, LT Griffin-Thomas - Expert reviews in molecular medicine, 2009 - cambridge.org
There is now a large body of data indicating that the cannabinoid receptor type 2 (CB2) is
linked to a variety of immune events. This functional relevance appears to be most salient in …

An overview of the cannabinoid type 2 receptor system and its therapeutic potential

B Bie, J Wu, JF Foss, M Naguib - Current Opinion in …, 2018 - journals.lww.com
An overview of the cannabinoid type 2 receptor system and it... : Current Opinion in
Anesthesiology An overview of the cannabinoid type 2 receptor system and its therapeutic …

Cannabinoid receptors as therapeutic targets

K Mackie - Annu. Rev. Pharmacol. Toxicol., 2006 - annualreviews.org
▪ Abstract CB1 and CB2 cannabinoid receptors are the primary targets of endogenous
cannabinoids (endocannabinoids). These G protein–coupled receptors play an important …

Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation

S Rom, Y Persidsky - Journal of Neuroimmune Pharmacology, 2013 - Springer
An accumulating body of evidence suggests that endocannabinoids and cannabinoid
receptors type 1 and 2 (CB 1, CB 2) play a significant role in physiologic and pathologic …