Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Lens opacities, or cataract (s), may be inherited as a classic Mendelian disorder usually with
early-onset or, more commonly, acquired with age as a multi-factorial or complex trait. Many …

Developmental transcription factors important in early neuron specification and
differentiation often remain expressed in the adult brain. However, how these transcription …

Mitochondria have been largely described as the powerhouse of the cell and recent findings
demonstrate that this organelle is fundamental for neurogenesis. The mechanisms …

The non-motor symptoms (NMS) of Parkinson's disease (PD) occur in roughly 90% of
patients, have a profound negative impact on their quality of life, and often go undiagnosed …

Although a number of genetic causes have been identified, many ASD conditions are still
awaiting genetic elucidation. The majority of characterized ASD genes encode transcription …

Background Oxidative stress is heavily implicated in the pathogenic process of Parkinson's
disease. Varying capacity to detoxify radical oxygen species through induction of phase II …

microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse
cellular and developmental processes. Many miRNAs are expressed specifically in the …

Abstract Background The transcription factor Nrf2, encoded by the NFE2L2 gene, is an
important regulator of the cellular protection against oxidative stress. Parkinson's disease is …

The role of developmental transcription factors in maintenance of neuronal properties and in
disease remains poorly understood. Lmx1a and Lmx1b are key transcription factors required …