In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …

Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Among genetic alterations in human cancers, mutations in the tumor suppressor p53 gene
are the most common, occurring in over 50% of human cancers. The majority of p53 …

The mutual and interdependent interaction between tumor and its microenvironment is a
crucial topic in cancer research. Recently, it was reported that targeting stromal events could …