Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …

In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

Background: Benznidazole is recommended for treatment of Chagas infection. Effects of
combination therapy with benznidazole and posaconazole have not been tested in …

A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

The CYP51 family is an intriguing subject for fundamental P450 structure/function studies
and is also an important clinical drug target. This review updates information on the variety …

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions of
people in the Americas and across the world, leading to considerable morbidity and …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

This article presents an overview of the currently available drugs nifurtimox (NFX) and
benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas …

Chagas disease, or American trypanosomiasis, caused by Trypanosoma cruzi parasite
infection is endemic in Latin America and presents an increasing clinical challenge due to …

The development of treatment protocols with reduced toxicity and equivalent or improved
efficacy for Trypanosoma cruzi infection is a priority. We tested the effectiveness of …