Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

The effective design of combinatorial libraries to balance fitness and diversity facilitates the
engineering of useful enzyme functions, particularly those that are poorly characterized or …

The enantioselective reduction of enamides is an efficient and atom-economical way to
construct chiral amine motifs. In contrast to transition-metal complex based asymmetric …

Enzymes capable of assimilating fluorinated feedstocks are scarce. This situation poses a
challenge for the biosynthesis of fluorinated compounds used in pharmaceuticals …

Visible light-driven pyridoxal radical biocatalysis has emerged as a promising strategy for
the stereoselective synthesis of valuable noncanonical amino acids (ncAAs). Previously, the …

The photoinduced unnatural reactions catalyzed by flavin-dependent enzymes usually
proceed through reduction pathways, which required the use of electron-sacrificial reagents …

Despite their intriguing photophysical and photochemical activities, naturally occurring
photoenzymes have not yet been repurposed for new-to-nature activities. Here we …

Artificial photoenzymes with novel catalytic modes not found in nature are in high demand;
yet, they also present significant challenges in the field of biocatalysis. In this study, a …

Creating artificial enzymes by the genetic incorporation of noncanonical amino acids with
catalytic side chains would expand the enzyme chemistries that have not been discovered in …