Enterovirus A71 proteins: structure and function
J Yuan, L Shen, J Wu, X Zou, J Gu, J Chen… - Frontiers in …, 2018 - frontiersin.org
Enterovirus A71 (EV-A71) infection has grown to become a serious threat to global public
health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and …
health. It is one of the major causes of hand, foot, and mouth disease (HFMD) in infants and …
Innate immunity and immune evasion by enterovirus 71
Enterovirus 71 (EV71) is a major infectious disease affecting millions of people worldwide
and it is the main etiological agent for outbreaks of hand foot and mouth disease (HFMD) …
and it is the main etiological agent for outbreaks of hand foot and mouth disease (HFMD) …
Design, synthesis, and biological evaluation of peptidomimetic aldehydes as broad-spectrum inhibitors against enterovirus and SARS-CoV-2
W Dai, D Jochmans, H Xie, H Yang, J Li… - Journal of medicinal …, 2021 - ACS Publications
A novel series of peptidomimetic aldehydes was designed and synthesized to target 3C
protease (3Cpro) of enterovirus 71 (EV71). Most of the compounds exhibited high antiviral …
protease (3Cpro) of enterovirus 71 (EV71). Most of the compounds exhibited high antiviral …
Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3
X Lei, Z Sun, X Liu, Q Jin, B He, J Wang - Journal of virology, 2011 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) causes hand-foot-and-mouth disease and neurological
complications in young children. Although the underlying mechanisms remain obscure …
complications in young children. Although the underlying mechanisms remain obscure …
The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses
X Lei, X Liu, Y Ma, Z Sun, Y Yang, Q Jin, B He… - Journal of …, 2010 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) is a human pathogen that induces hand, foot, and mouth
disease and fatal neurological diseases. Immature or impaired immunity is thought to …
disease and fatal neurological diseases. Immature or impaired immunity is thought to …
Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses
X Lei, X Xiao, Q Xue, Q Jin, B He, J Wang - Journal of virology, 2013 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) is a positive-stranded RNA virus which is capable of
inhibiting innate immunity. Among virus-encoded proteins, the 3C protein compromises the …
inhibiting innate immunity. Among virus-encoded proteins, the 3C protein compromises the …
Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation
Identification of novel cellular proteins as substrates to viral proteases would provide a new
insight into the mechanism of cell–virus interplay. Eight nuclear proteins as potential targets …
insight into the mechanism of cell–virus interplay. Eight nuclear proteins as potential targets …
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds
CC Lee, CJ Kuo, TP Ko, MF Hsu, YC Tsui… - Journal of Biological …, 2009 - ASBMB
Human coxsackievirus (CV) belongs to the picornavirus family, which consists of over 200
medically relevant viruses. In picornavirus, a chymotrypsin-like protease (3C pro) is required …
medically relevant viruses. In picornavirus, a chymotrypsin-like protease (3C pro) is required …
Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation
JY Lin, ML Li, SR Shih - Nucleic acids research, 2009 - academic.oup.com
An internal ribosomal entry site (IRES) that directs the initiation of viral protein translation is a
potential drug target for enterovirus 71 (EV71). Regulation of internal initiation requires the …
potential drug target for enterovirus 71 (EV71). Regulation of internal initiation requires the …
Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex
X Lei, N Han, X Xiao, Q Jin, B He, J Wang - Journal of virology, 2014 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) causes hand, foot, and mouth disease in young children
and infants. Severe infection with EV71 can lead to various neurological complications or …
and infants. Severe infection with EV71 can lead to various neurological complications or …