Over the last decade the identification of mutations in the receptors for fibroblast growth
factors (FGFs) has defined essential roles for FGF signaling in both endochondral and …

Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …

The growing interest in scaffolding design and increasing research programs dedicated to
regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While …

Fibroblast growth factors (FGFs) play important roles in skeletal development and postnatal
osteogenesis. FGF signaling controls bone formation by regulating the expression of various …

During skull development, the cranial connective tissue framework undergoes
intramembranous ossification to form skull bones (calvaria). As the calvarial bones advance …

Phenotypic variation across mammals is extensive and reflects their ecological
diversification into a remarkable range of habitats on every continent and in every ocean …

In addition to their role in skull growth, sutures are sites of flexibility between the more rigid
bones. Depending on the suture, predominant loading during life may be either tensile or …

Background: Adipose-derived mesenchymal cells are multipotent progenitor cells derived
from the vascular-stromal compartment of adipose tissue. Although we have recently shown …

The term craniosynostosis was first used in 1830 by Otto to describe the premature fusion of
cranial sutures (Otto, 1830). Since this first identification of craniosynostosis as a distinct …

Craniosynostosis describes conditions in which one or more sutures of the infant skull are
prematurely fused, resulting in facial deformity and delayed brain development …