Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …

Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly
enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent …

Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail,
less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is …

Chronic HIV-1 infection is generally characterized by progressive CD4+ T cell depletion due
to direct and bystander death that is closely associated with persistent HIV-1 replication and …

The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries
and regions of the world, and is undoubtedly the defining public-health crisis of our time …

The HIV accessory protein negative factor (Nef) is one of the earliest and most abundantly
expressed viral proteins. It is also found in the serum of infected individuals (Caby MP …

Thorough research on HIV is progressively enabling us to understand the intricate
mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and …

The mechanism by which CD4 T cells are depleted in HIV-infected hosts remains poorly
understood. In ex vivo cultures of human tonsil tissue, CD4 T cells undergo a pronounced …

Guanylate binding proteins (GBPs) are an interferon (IFN)-inducible subfamily of guanosine
triphosphatases (GTPases) with well-established activity against intracellular bacteria and …