Diversity and versatility of p38 kinase signalling in health and disease
B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …
coordinated manner is key for survival and involves various signalling networks. Over the …
Cell competition in development, homeostasis and cancer
SM van Neerven, L Vermeulen - Nature Reviews Molecular Cell …, 2023 - nature.com
Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …
that collectively regulate tissue architecture and function. To ensure the highest tissue …
YAP and TAZ: a signalling hub of the tumour microenvironment
F Zanconato, M Cordenonsi, S Piccolo - Nature Reviews Cancer, 2019 - nature.com
YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …
tumours and their functions in cancer cells are the focus of intense investigation. These …
Emerging mechanisms of cell competition
NE Baker - Nature Reviews Genetics, 2020 - nature.com
The growth and survival of cells within tissues can be affected by 'cell competition'between
different cell clones. This phenomenon was initially recognized between wild-type cells and …
different cell clones. This phenomenon was initially recognized between wild-type cells and …
Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
Vertex models: from cell mechanics to tissue morphogenesis
Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …
large number of cells. Vertex model simulations for tissue mechanics have been developed …
Topological defects in epithelia govern cell death and extrusion
Epithelial tissues (epithelia) remove excess cells through extrusion, preventing the
accumulation of unnecessary or pathological cells. The extrusion process can be triggered …
accumulation of unnecessary or pathological cells. The extrusion process can be triggered …
Cell competition: the winners and losers of fitness selection
S Bowling, K Lawlor, TA Rodríguez - Development, 2019 - journals.biologists.com
The process of cell competition results in the elimination of cells that are viable but 'less
fit'than surrounding cells. Given the highly heterogeneous nature of our tissues, it seems …
fit'than surrounding cells. Given the highly heterogeneous nature of our tissues, it seems …
Cell competition in intratumoral and tumor microenvironment interactions
TM Parker, K Gupta, AM Palma, M Yekelchyk… - The EMBO …, 2021 - embopress.org
Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …
Outcompeting cancer
M Vishwakarma, E Piddini - Nature Reviews Cancer, 2020 - nature.com
The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …
environment, and indeed throughout epithelial tissues, cells experience competition with …