Diversity and versatility of p38 kinase signalling in health and disease

B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Cell competition in development, homeostasis and cancer

SM van Neerven, L Vermeulen - Nature Reviews Molecular Cell …, 2023 - nature.com
Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …

YAP and TAZ: a signalling hub of the tumour microenvironment

F Zanconato, M Cordenonsi, S Piccolo - Nature Reviews Cancer, 2019 - nature.com
YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

Emerging mechanisms of cell competition

NE Baker - Nature Reviews Genetics, 2020 - nature.com
The growth and survival of cells within tissues can be affected by 'cell competition'between
different cell clones. This phenomenon was initially recognized between wild-type cells and …

Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine

Y Xin, K Li, M Huang, C Liang, D Siemann, L Wu, Y Tan… - Oncogene, 2023 - nature.com
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Vertex models: from cell mechanics to tissue morphogenesis

S Alt, P Ganguly, G Salbreux - … Transactions of the …, 2017 - royalsocietypublishing.org
Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

Topological defects in epithelia govern cell death and extrusion

TB Saw, A Doostmohammadi, V Nier, L Kocgozlu… - Nature, 2017 - nature.com
Epithelial tissues (epithelia) remove excess cells through extrusion, preventing the
accumulation of unnecessary or pathological cells. The extrusion process can be triggered …

Cell competition: the winners and losers of fitness selection

S Bowling, K Lawlor, TA Rodríguez - Development, 2019 - journals.biologists.com
The process of cell competition results in the elimination of cells that are viable but 'less
fit'than surrounding cells. Given the highly heterogeneous nature of our tissues, it seems …

Cell competition in intratumoral and tumor microenvironment interactions

TM Parker, K Gupta, AM Palma, M Yekelchyk… - The EMBO …, 2021 - embopress.org
Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …

Outcompeting cancer

M Vishwakarma, E Piddini - Nature Reviews Cancer, 2020 - nature.com
The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …