Therapies for stroke have remained elusive in the past despite the great relevance of this
pathology. However, recent results have provided strong evidence that postsynaptic density …

Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …

Cellular signaling is often propagated by multivalent interactions. Multivalency creates
avidity, allowing stable biophysical recognition. Multivalency is an attractive strategy for …

Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic
density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-d …

Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

Inhibiting the protein–protein interaction (PPI) between the transcription factor Nrf2 and its
repressor protein Keap1 has emerged as a promising strategy to target oxidative stress in …

The PDZ domain is a protein–protein interacting module that plays an important role in the
organization of signaling complexes. The recognition of short intrinsically disordered C …

Human genome-wide association studies (GWAS) suggest a functional role for central
glutamate receptor signaling and plasticity in body weight regulation. Here, we use UK …

The interactions of the AMPA receptor (AMPAR) auxiliary subunit Stargazin with PDZ
domain–containing scaffold proteins such as PSD-95 are critical for the synaptic stabilization …

The complex between the N-methyl-d-aspartate receptor (NMDAR), neuronal nitric oxide
synthase (nNOS), and the postsynaptic density protein-95 (PSD-95) is an attractive …