The remarkable number of new molecular entities approved per year as parenteral drugs,
such as biologics and complex active pharmaceutical ingredients, calls for innovative and …

The advancement of delivery tools for therapeutic agents has brought several novel
formulations with increased drug loading, sustained release, targeted delivery, and …

In this study, we reported the development and the physico-chemical characterization of
poloxamer 407 (PL407) and poloxamer 188 (PL188) binary systems as hydrogels for …

The mechanism of drug release from complex dosage forms, such as multivesicular
liposomes (MVLs), is complex and oftentimes sensitive to the release environment. This …

Multivesicular liposomes (MVLs) are non-concentric, lipid-based micron-sized spherical
particles. The usage of MVL for sustained drug delivery has seen progression over the last …

Medicinal plants are candidates for the discovery of potential new anti-inflammatory agents.
Curcumin is the active compound found in turmeric root, which has high anti-inflammatory …

Colorectal cancer with peritoneal metastasis has a poor prognosis because of inadequate
responses to systemic chemotherapy. Cytoreductive surgery followed by intraperitoneal (IP) …

Drug development is a key point in the research of new therapeutic treatments for increasing
maximum drug loading and prolonged drug effect. Encapsulation of drugs into multivesicular …

Extended-release local anesthetics (LAs) have drawn increasing attention with their
promising role in improving analgesia and reducing adverse events of LAs. Nano-structured …

The aim of the present study was to develop a novel dosage form of multivesicular
liposomes for oleanolic acid (OA) to overcome its poor solubility, prolong therapeutic drug …