Neuroinflammation is involved in the progression or secondary injury of multiple brain
conditions, including stroke and neurodegenerative diseases. Alarmins, also known as …

The high-mobility group box (HMGB) family consists of four DNA-binding proteins that
regulate chromatin structure and function. In addition to their intracellular functions, recent …

Food dyes, including a broad spectrum of natural and synthetic dyes, are considered
potentially hazardous materials that might pollute the environment and threaten human …

The ability of a therapeutic compound to bind to proteins is critical for characterizing its
therapeutic impacts. We have selected quercetin (Qu), a most common flavonoid found in …

Highly negatively charged segments containing only aspartate or glutamate residues (“D/E
repeats”) are found in many eukaryotic proteins. For example, the C-terminal 30 residues of …

Non‐alcoholic fatty liver disease (NAFLD), characterized by an increase in hepatic
triglyceride (TG) content, is the most common liver disease worldwide. Aging has been …

Anaplastic lymphoma kinase (ALK) is validated as a therapeutic molecular target in multiple
malignancies, such as non-small cell lung cancer (NSCLC). However, the feasibility of …

The extensive clinical and genetic heterogeneity of congenital limb malformation calls for
comprehensive genome-wide analysis of genetic variation. Genome sequencing (GS) has …

HMGB3 protein belongs to the group of HMGB proteins from the superfamily of nuclear
proteins with high electrophoretic mobility. HMGB proteins play an active part in almost all …

Chronic and persistent inflammation associated with excessive high mobility group protein 1
(HMGB1) is a risk factor for various diseases. Dietary intake of kaempferol has been proven …