Emerging roles of PIWI-interacting RNAs (piRNAs) and PIWI proteins in head and neck cancer and their potential clinical implications

T Chattopadhyay, P Biswal, A Lalruatfela… - Biochimica et Biophysica …, 2022 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) are among the well-known neoplasms
originating in the oral cavity, pharynx, and larynx. Despite advancements in chemotherapy …

Retracted: CRNDE promotes malignant progression of glioma by attenuating miR-384/PIWIL4/STAT3 Axis

J Zheng, X Liu, P Wang, Y Xue, J Ma, C Qu, Y Liu - Molecular therapy, 2016 - cell.com
Colorectal neoplasia differentially expressed (CRNDE) is the most upregulated long
noncoding RNA (lncRNA) in glioma. Herein, the function and potential molecular …

Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer

W Weng, N Liu, Y Toiyama, M Kusunoki, T Nagasaka… - Molecular cancer, 2018 - Springer
Background Emerging evidence suggests that PIWI-interacting RNAs (piRNAs) may be
important epigenetic regulators of gene expression in human cancers; however, their …

piRNAs and PIWI proteins as diagnostic and prognostic markers of genitourinary cancers

K Hanusek, S Poletajew, P Kryst… - Biomolecules, 2022 - mdpi.com
piRNAs (PIWI-interacting RNAs) are small non-coding RNAs capable of regulation of
transposon and gene expression. piRNAs utilise multiple mechanisms to affect gene …

Circulating exosomal small RNAs are promising non‐invasive diagnostic biomarkers for gastric cancer

L Ge, N Zhang, D Li, Y Wu, H Wang… - Journal of cellular and …, 2020 - Wiley Online Library
Dysregulation of small non‐coding RNA (ncRNA) is associated with various human
diseases including cancer. This study aimed to evaluate the circulating exosomal small …

Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA

BPU Perera, ZTY Tsai, ML Colwell, TR Jones… - Epigenetics, 2019 - Taylor & Francis
Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWI
proteins for transposon silencing via DNA methylation and are highly expressed and …

piR-651 promotes tumor formation in non-small cell lung carcinoma through the upregulation of cyclin D1 and CDK4

D Li, Y Luo, Y Gao, Y Yang… - International …, 2016 - spandidos-publications.com
Piwi-interacting RNAs (piRNAs or piRs) are a novel class of non-coding RNAs that
participate in germline development by silencing transposable elements and regulating …

Prognosis of clear cell renal cell carcinoma patients stratified by age: A research relied on SEER database

Z Liao, D Wang, N Song, Y Xu, H Ge, Z Peng - Frontiers in oncology, 2022 - frontiersin.org
Objective Clear cell renal cell carcinoma may affect patients of any age. To date, there are
only a limited number of large data studies on renal clear cell carcinoma in different age …

Decreased expression levels of PIWIL1, PIWIL2, and PIWIL4 are associated with worse survival in renal cell carcinoma patients

R Iliev, M Stanik, M Fedorko, A Poprach… - OncoTargets and …, 2016 - Taylor & Francis
Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs
involved in silencing of transposable elements and in sequence-specific chromatin …

Emerging roles for PIWI proteins in cancer

Y Tan, L Liu, M Liao, C Zhang, S Hu… - Acta biochimica et …, 2015 - academic.oup.com
It is generally accepted that PIWI proteins are predominately expressed in the germline but
absent in somatic tissues. Their best-characterized role is to suppress transposon …