Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies
S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …
With the global population aged 65 and over growing faster than all other age groups, the …
Biochemistry of peroxynitrite and protein tyrosine nitration
G Ferrer-Sueta, N Campolo, M Trujillo… - Chemical …, 2018 - ACS Publications
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …
Free radical damage in ischemia‐reperfusion injury: an obstacle in acute ischemic stroke after revascularization therapy
MS Sun, H Jin, X Sun, S Huang… - Oxidative medicine …, 2018 - Wiley Online Library
Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular …
Thrombolysis with recombinant tissue plasminogen activator and endovascular …
Free radicals, natural antioxidants, and their reaction mechanisms
The normal biochemical reactions in our body, increased exposure to the environment, and
higher levels of dietary xenobiotic's result in the generation of reactive oxygen species …
higher levels of dietary xenobiotic's result in the generation of reactive oxygen species …
Edaravone dexborneol versus edaravone alone for the treatment of acute ischemic stroke: a phase III, randomized, double-blind, comparative trial
J Xu, A Wang, X Meng, G Yalkun, A Xu, Z Gao, H Chen… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Edaravone dexborneol, comprised of 2 active ingredients,
edaravone and (+)-borneol, has been developed as a novel neuroprotective agent with …
edaravone and (+)-borneol, has been developed as a novel neuroprotective agent with …
Targeting NMDA receptors in stroke: new hope in neuroprotection
QJ Wu, M Tymianski - Molecular brain, 2018 - Springer
Abstract NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …
neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be …
Peroxynitrite, a stealthy biological oxidant
R Radi - Journal of Biological Chemistry, 2013 - ASBMB
Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …
Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
Treatments for acute ischaemic stroke continue to evolve after the superior value of
endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately …
endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately …
Role of oxidative modifications in atherosclerosis
R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
[HTML][HTML] Uric acid, hyperuricemia and vascular diseases
Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high
levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological …
levels of blood uric acid, is the major etiological factor of gout. A number of epidemiological …