Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

Identifying how small molecules act to kill malaria parasites can lead to new “chemically
validated” targets. By pressuring Plasmodium falciparum asexual blood stage parasites with …

In high-transmission regions, we expect parasite lineages within complex malaria infections
to be unrelated due to parasite inoculations from different mosquitoes. This project was …

Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …

Next-generation sequencing (NGS) technologies are increasingly being used to address a
diverse range of biological and epidemiological questions. The current understanding of …

Background Studies have demonstrated the protective role of antibodies against malaria.
Young children are known to be particularly vulnerable to malaria, pointing to the evolution …

Immunity to Plasmodium falciparum is non-sterilising, thus individuals residing in malaria-
endemic areas are at risk of infection throughout their lifetime. Here we seek to find a …

Background Deep sequencing of targeted genomic regions is becoming a common tool for
understanding the dynamics and complexity of Plasmodium infections, but its lower limit of …

Simple Summary Malaria is one of the most severe life-threatening human vector-borne
diseases worldwide today, leading to high mortality. Children under the age of five and …