Lab-on-a-chip: microfluidics in drug discovery
PS Dittrich, A Manz - Nature reviews Drug discovery, 2006 - nature.com
Miniaturization can expand the capability of existing bioassays, separation technologies and
chemical synthesis techniques. Although a reduction in size to the micrometre scale will …
chemical synthesis techniques. Although a reduction in size to the micrometre scale will …
Overview of single-cell analyses: microdevices and applications
S Lindström, H Andersson-Svahn - Lab on a Chip, 2010 - pubs.rsc.org
Numerous microdevices developed for single-cell analyses have been presented in the last
decades. Practical usefulness in biological and clinical settings has become an important …
decades. Practical usefulness in biological and clinical settings has become an important …
Continuous inertial focusing, ordering, and separation of particles in microchannels
Under laminar flow conditions, when no external forces are applied, particles are generally
thought to follow fluid streamlines. Contrary to this perspective, we observe that flowing …
thought to follow fluid streamlines. Contrary to this perspective, we observe that flowing …
Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays
D Di Carlo, N Aghdam, LP Lee - Analytical chemistry, 2006 - ACS Publications
High-quality single-cell data are required for a quantitative systems biology description of
cellular function. However, data of this type are difficult and time-consuming to collect using …
cellular function. However, data of this type are difficult and time-consuming to collect using …
Microfabricated cell sorter
The invention provides a microfabricated device for sorting cells based on a desired
characteristic, for example, reporter-labeled cells can be sorted by the presence or level of …
characteristic, for example, reporter-labeled cells can be sorted by the presence or level of …
Integrated active flux microfluidic devices and methods
SR Quake, HP Chou - US Patent 6,767,706, 2004 - Google Patents
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or
other molecules associated with a particular disease. The devices and methods of the …
other molecules associated with a particular disease. The devices and methods of the …
Microfabricated cell sorter for chemical and biological materials
The invention provides a microfabricated device for Sorting cells based on a desired
characteristic, for example, reporter labeled cells can be sorted by the presence or level of …
characteristic, for example, reporter labeled cells can be sorted by the presence or level of …
Suspension array technology: evolution of the flat-array paradigm
JP Nolan, LA Sklar - TRENDS in Biotechnology, 2002 - cell.com
Suspension arrays of microspheres analyzed using flow cytometry offer a new approach to
multiplexed assays for large-scale screening applications. By optically encoding micron …
multiplexed assays for large-scale screening applications. By optically encoding micron …
Three dimensional, sheathless, and high‐throughput microparticle inertial focusing through geometry‐induced secondary flows
The ability to continuously control microparticle position tightly in a confined microchannel is
remarkably useful for a wide range of biomedical studies.[1–3] In order to achieve particle …
remarkably useful for a wide range of biomedical studies.[1–3] In order to achieve particle …