Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …

Obesity is gaining acceptance as a serious primary health burden that impairs the quality of
life because of its associated complications, including diabetes, cardiovascular diseases …

Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) is a master regulator
of mitochondrial biogenesis. Reduced PGC-1α abundance is linked to skeletal muscle …

It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …

Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal
muscle clock has never been explored. We generated conditional and inducible mouse …

Scarring of the kidney is a major public health concern, directly promoting loss of kidney
function. To understand the role of microRNA (miRNA) in the progression of kidney scarring …