New perspectives in glutamate and anxiety

CR Bermudo-Soriano, MM Perez-Rodriguez… - Pharmacology …, 2012 - Elsevier
Anxiety and stress-related disorders, namely posttraumatic stress disorder (PTSD),
generalized anxiety disorder (GAD), obsessive–compulsive disorder (ODC), social and …

Aliphatic polyamines in physiology and diseases

D Ramani, JP De Bandt, L Cynober - Clinical nutrition, 2014 - Elsevier
Aliphatic polyamines are a family of polycationic molecules derived from decarboxylation of
the amino acid ornithine that classically comprise three molecules: putrescine, spermidine …

Pharmacological alternatives for the treatment of neurodegenerative disorders: Wasp and bee venoms and their components as new neuroactive tools

J Silva, V Monge-Fuentes, F Gomes, K Lopes… - Toxins, 2015 - mdpi.com
Neurodegenerative diseases are relentlessly progressive, severely impacting affected
patients, families and society as a whole. Increased life expectancy has made these …

Calcium‐permeable AMPA receptors are involved in the induction and expression of l‐DOPA‐induced dyskinesia in Parkinson's disease

C Kobylecki, MA Cenci, AR Crossman… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 114, 409–511. Abstract Overactivity of striatal α‐amino‐3‐hydroxy‐5‐
methyl‐4‐isoxazolepropionic acid (AMPA) glutamate receptors is implicated in the …

Neurotoxins from invertebrates as anticonvulsants: from basic research to therapeutic application

MR Mortari, AOS Cunha, LB Ferreira… - Pharmacology & …, 2007 - Elsevier
Invertebrate venoms have attracted considerable interest as a potential source of bioactive
substances, especially neurotoxins. These molecules have proved to be extremely useful …

Targeting ionotropic receptors with polyamine-containing toxins☆

IR Mellor, PNR Usherwood - Toxicon, 2004 - Elsevier
This review summarises current knowledge of polyamine-containing spider toxins and their
interactions with ionotropic receptors of invertebrate and vertebrate excitable cells. Their …

Probing TARP modulation of AMPA receptor conductance with polyamine toxins

AC Jackson, AD Milstein, D Soto, M Farrant… - Journal of …, 2011 - Soc Neuroscience
The properties of synaptic AMPA receptors (AMPARs) depend on their subunit composition
and association with transmembrane AMPAR regulatory proteins (TARPs). Although both …

Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene–environment interactions with childhood/adolescent physical …

M Sokolowski, YJ Ben-Efraim, J Wasserman… - Molecular …, 2013 - nature.com
The complex etiology of suicidal behavior has frequently been investigated in relation to
monoaminergic neurotransmission, but other neurosystems have shown alterations as well …

Evidence of altered polyamine concentrations in cerebral cortex of suicide completers

GG Chen, LM Fiori, L Moquin, A Gratton… - …, 2010 - nature.com
Recent studies have implicated alterations in the expression of polyamine-related genes in
the brains of suicide completers including widespread downregulation of …

Design of antagonists for NMDA and AMPA receptors

KV Bolshakov, KH Kim, NN Potapjeva, VE Gmiro… - …, 2005 - Elsevier
Determinants of antagonism of NMDA and calcium permeable AMPA receptor channels by
organic cations were studied using several homologous series of mono-and dicationic …