SOX4 is an essential developmental transcription factor that regulates stemness,
differentiation, progenitor development, and multiple developmental pathways including …

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …

Background Dysregulation of the epitranscriptome causes abnormal expression of
oncogenes in the tumorigenic process. Previous studies have shown that NAT10 can …

TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …

Liver cancer has a tendency to develop asymptomatically in patients, so most patients are
diagnosed at a later stage. Accumulating evidence implicates that liver tumour-initiating cells …

The zebrafish has proven to be a valuable model organism for studying hematopoiesis, but
relatively little is known about zebrafish immune cell development and functional diversity …

Abstract Background Long non-coding RNAs (lncRNAs) play a variety of cellular roles,
including regulation of transcription and translation, leading to alterations in gene …

Oncogenic transcription factors such as RUNX1/ETO, which is generated by the
chromosomal translocation t (8; 21), subvert normal blood cell development by impairing …

The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis
and cancer progression. However, the role of SOX12 and the mechanism by which it is …

Mutations in acute myeloid leukemia (AML)-associated oncogenes often arise in
hematopoietic stem cells (HSCs) and promote acquisition of leukemia stem cell (LSC) …