Context Bladder cancer (BC) represents a significant health problem due to the potential
morbidity and mortality associated with disease burden, which has remained largely …

Bladder cancer is a highly prevalent disease and is associated with substantial morbidity,
mortality and cost. Environmental or occupational exposures to carcinogens, especially …

Context The incidence of bladder cancer is three to four times greater in men than in women.
However, women are diagnosed with more advanced disease at presentation and have less …

Infectious diseases have a profound impact on our health and many studies suggest that
host genetics play a major role in the pathogenesis of most of them. We perform 23 genome …

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock
of hair donated by an Aboriginal man from southern Western Australia in the early 20th …

Background Genomic regions identified by genome-wide association studies (GWAS) for
bladder cancer risk provide new insights into etiology. Objective To identify new …

We conducted a multi-stage, genome-wide association study of bladder cancer with a
primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of …

Bladder cancer is mainly a disease of aging; its incidence and prevalence increase around
the sixth decade and peak in the seventh to eighth decade of life. It is the ninth most …

Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs
during aging, particularly in smokers. We investigated whether mLOY was associated with …

An outstanding question in human genetics has been the degree to which adaptation occurs
from standing genetic variation or from de novo mutations. Here, we combine several …