Abstract Bioprinting of 3-dimensional (3D) micro-patterned structures could be a promising
approach to mimic complex organs in vivo. This technique holds promise for generating …

The occurrence of various liver diseases can lead to organ failure of the liver, which is one of
the leading causes of mortality worldwide. Liver tissue engineering see the potential for …

The cell spheroid technology, which greatly enhances cell-cell interactions, has gained
significant attention in the development of in vitro liver models. However, existing cell …

Non-alcoholic fatty liver disease (NAFLD) has become the world's most common chronic
liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development …

Bioprinting, as a groundbreaking technology, enables the fabrication of biomimetic tissues
and organs with highly complex structures, multiple cell types, mechanical heterogeneity …

In vitro drug screening endeavors to replicate cellular states closely resembling those
encountered in vivo, thereby maximizing the fidelity of drug effects and responses within the …

Background Despite considerable advancements in identifying factors contributing to the
development of hepatocellular carcinoma (HCC), the pathogenesis of HCC remains unclear …

Non-alcoholic fatty liver disease (NAFLD) is a high-prevalence and progressive disorder.
Due to lack of reliable in vitro models to recapitulate the consecutive phases, the exact …

Hydrogels derived from the decellularized extracellular matrix (dECM) are widely used in 3D
bioprinting, mainly because they are recapitulating the native tissue microenvironment and …

Three-dimensional (3D) hepatocyte models have become a research hotspot for evaluating
drug metabolism and hepatotoxicity. Compared to two-dimensional (2D) cultures, 3D …